lucose degradation products and the peritoneal mesothelium.

Abstract\n customary heat-sterilized, glucose-based peritoneal dialysis (PD) fluids contain square amounts of glucose degradation products (GDPs) such as aldehydes and dicarbonyl compounds (glyoxal, methylglyoxal). These GDPs have been shown to impair cell functions in various in vitro experimental models. In peritoneal mesothelial cells, GDPs dose-dependently inhibit cell proliferation and intermediary synthesis. In addition, some GDPs potently promote generation of modernistic glycation end-products ( senesces). Immunohistochemistry finds AGEs in the peritoneal membrane of chronic continuous ambulant peritoneal dialysis (CAPD) patients, suggesting that peritoneal AGE accumulation may be involved in chronicperitoneal fibrosis. The administration of GDPs might be prevented by filter-sterilization of PD fluids. Another cream is to separate the glucose and the buffer scheme in dual-chambered or multi-chambered containers. In these systems, the glucose is kept in a separate com partment at risque concentration and very let loose pH-both conditions being known to defame the degree of glucose decomposition during autoclaving. sign experimental evidence suggests that these novel, multi-chambered fluids significantly improve in vitro biocompatibility; however, the clinical relevance of these results remains to be established in clinical trials.If you want to get a full essay, order it on our website:

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